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 Dr.Shruti Bhat, Star formulator and Ace leader within pharmaceutical R&D,a specialist with hiTech formulations and quality-by-design. Shruti brings to you some highlights from current pharma and clinical research news, views and data. Oral Contraceptives May Reduce Risk Of Death From Any Cause In Women. "Women who have taken the Pill at any stage in their life are less likely to die from any cause -- including heart disease and all types of cancer -- than those who have never taken the oral contraceptive," according to research published online in the British Medical Journal. The study of "more than 46,000 women revealed ... FDA Proposes To Remove Orthostatic Hypotension Drug From Market. The Wall Street Journalreported that the FDA proposed to remove brand and generic versions of low-blood pressure drug ProAmatine (midodrine hydrochloride) from the market because required post-marketing studies on the drug's effectiveness have yet to be conducted. The drug was approved under the FDA's accelerated approval program, and according to the Journal, this is the first time the agency is requesting a drug to be removed ... Malaria sufferers might be able to protect themselves against life-threatening bouts of the disease by taking a single course of antibiotics, research in mice has shown. Preventive treatment with 'needle-free' antibiotic vaccines could be used to control the infection in areas with high levels of transmission, a study published in Science Translational Medicine suggests. There are still no available vaccines against malaria. And although some antibiotics with anti-malarial properties, such as doxycycline, that kill the parasites directly are already ... Hormonal Contraceptives May Not Be Effective In Overweight Or Obese Women. Hormonal contraceptives may not be effective for contraception in overweight or obese women," according to a review published online in the Cochrane Database of Systematic Reviews. After performing a literature review encompassing "11 trials enrolling a total of 39,531 women... Osteoporosis drug linked to irregular heart beat. Women who take popular osteoporosis drug alendronate, known more commonly as Fosamax, are twice as likely to develop a common form of irregular heartbeat compared to those who have never taken it, suggests a new study published in the journal Archives of Internal Medicine. Researchers analyzed data from more than 700 women who had been diagnosed with atrial fibrillation, or irregular heartbeat, in a three-year period and compared them to a control group of more than 900 randomly selected women. They found a nearly two-fold increase in risk for developing atrial fibrillation among those women who had ever taken alendronate … More at http://www.pharm-education.com/2010/08/malaria-sufferers-might-be-able-to.html References: http://online.wsj.com/article/SB10001424052748704868604575433703888376436.html http://www.google.com/hostednews/afp/article/ALeqM5gX0oxFR_ZpHn-RyPL8JkXqWD4PNg http://www.usatoday.com/news/health/2010-08-16-fda-unproven-drug_N.htm http://www.medpagetoday.com/ProductAlert/Prescriptions/21699 http://www.latimes.com/health/boostershots/la-heb-hypotension-drug-20100816,0,53066.story?track=rss http://www.startribune.com/business/100813309.html?elr=KArks8c7PaP3E77K_3c::D3aDhUMEaPc:E7_ec7PaP3iUiD3aPc:_Yyc:aU7DYaGEP7vDEh7P:DiUs http://www.bizjournals.com/philadelphia/stories/2010/08/16/daily8.html http://www.theheart.org/article/1110411.do http://www.medscape.com/viewarticle/725103 http://www.ncbi.nlm.nih.gov/pubmed/20614470?dopt=Abstract http://stm.sciencemag.org/content/2/40/40ra49.full?ijkey=OAfu5Q9bUdH4Q&keytype=ref&siteid=scitransmed Disclaimer- The content of this article is intended to provide a general guide to the subject matter. Specialist advice should be sought about your specific circumstances. Http://www.drshrutibhat.comExpert at leading Pharmaceutical R&D. Translates innovative concepts to PROFITS. YouTube Channel : Http://www.youtube.com/user/ShrutiBhat10 Introducing ! A new blog- Http://www.PharmaceuticalCareerDevelopment.blogspot.com which contains articles on motivation, career counselling and coaching, job search strategies, personal branding etc. especially for pharma professionals. Do you have questions for the author?  Dr.Shruti Bhat, Star formulator and Ace leader within pharmaceutical R&D, a specialist with hiTech formulations and quality-by-design. Shruti brings to you some highlights from current pharma and clinical research news, views and data. Calcium Supplements May Be Linked To Increased Risk Of Heart Attack. Research data published in the online in the BMJ suggests that "Calcium supplements are a good way to keep your bones strong, but, they could lead to an increased risk for heart attack." Combined results from 11 randomized controlled trials of calcium supplements...involving more than 12,000 patients." The researchers "found a 31% increase in the risk of heart attack and smaller, non-significant increases in the risk of stroke and death." Although ... Starting HIV Therapy Earlier May Help Reduce Mortality Risk, Thwart TB Infection. The World Health Organization recommends patients start antiretroviral therapy when their CD4+ count drops to 350," as a "higher CD4+ count means greater infection-fighting ability because the immune system hasn't yet been depressed by the virus... More at http://www.pharm-education.com/2010/08/calcium-supplements-are-good-way-to.html Disclaimer- The content of this article is intended to provide a general guide to the subject matter. Specialist advice should be sought about your specific circumstances. Http://www.drshrutibhat.com Expert at leading Pharmaceutical R&D. Translates innovative concepts to PROFITS. YouTube Channel : Http://www.youtube.com/user/ShrutiBhat10 Do you have questions for the author? The first big win against skin cancer: Drug boosts survival in major study of deadly melanoma 06/11/2010
 Dr.Shruti Bhat, Leader Pharmaceutical R&D and Expert in hiTech formulation development for over 35 different therapeutic class of drugs moeities, brings to you some highlights from current pharma and clinical research news, views and data. Presented below are updates in Pharmaceutical and clinical research- Researchers have scored the first big win against melanoma, the deadliest form of skin cancer. An experimental drug significantly improved survival in a major study of people with very advanced disease. The results, reported Saturday at a cancer conference, left doctors elated. “We have not had any therapy that has prolonged survival” until now, said Dr. Lynn Schuchter of the Abramson Cancer Center at the University of Pennsylvania, a skin cancer specialist with no role in the study or ties to the drug’s maker. The drug, ipilimumab, (ip-ee-LIM-uh-mab), works by helping the immune system fight tumors. The federal Food and Drug Administration has pledged a quick review, and doctors think the drug could be available by the end of this year...Read more at http://www.pharm-education.com/2010/06/first-big-win-against-skin-cancer-drug.html Disclaimer- The content of this article is intended to provide a general guide to the subject matter. Specialist advice should be sought about your specific circumstances. Http://www.drshrutibhat.com Expert at leading Pharmaceutical R&D. Translates innovative concepts to PROFITS. YouTube Channel : Http://www.youtube.com/user/ShrutiBhat10 Shruti has initiated a new blog Http://www.PharmaceuticalCareerDevelopment.blogspot.com which contains articles on motivation, career counselling and coaching, job search strategies, personal branding etc. especially for pharma professionals. Do you have questions for the author?  Dr.Shruti Bhat, Leader Pharmaceutical R&D and Expert in hiTech formulation development for over 35 different therapeutic class of drugs moeities, brings to you some highlights from current pharma and clinical research news, views and data. Presented below are updates in Pharmaceutical and clinical research- Researchers Develop Vaccine That Prevents Breast Cancer From Developing In Mice. BBC News reported that "American scientists say they have developed a vaccine which has prevented breast cancer from developing in mice," according to a paper published ... Linaclotide Found To Relieve Chronic Constipation In Phase III Trials. MedPage Today reported that linaclotide, an "investigational drug to relieve chronic constipation was effective and caused no unexpected ... Pfizer Halts Late-Stage Clinical Study Of Sutent For Liver Cancer. The AP reported that Pfizer, Inc. announced that it had "stopped a late-stage clinical study of its drug Sutent [sunitinib] as a treatment for" hepatocellular ... Program May Help Physicians Improve Prescribing Practices For Patients With Hypertension. HealthDay reported that, "after taking part in a face-to-face program designed to review current research and guidelines, doctors made small improvements in the way they prescribed medicine for patients with high blood pressure," according to a study ... Study Suggests Newly Approved Prostate Cancer Vaccine Is Safe, Has Few Side Effects. The newly approved therapeutic prostate cancer vaccine, Provenge, is safe and has few side effects, according to a study scheduled to be presented at ... Blood-Sugar Meter That Connects With Gaming Systems May Help Children With Diabetes. The Washington Post reported that the FDA "recently approved Bayer HealthCare's Didget, a blood-sugar meter that can connect with the Nintendo DS and ... Rosuvastatin May Reduce Blood Lipid Linked To Coronary Artery Disease. MedPage Today reported, "In a study that specifically scrutinized the effects of statin therapy on triglycerides, researchers said that rosuvastatin (Crestor) significantly reduced ... Higher Lipitor Dose May Lower Heart Attack, Stroke Risk For Some Patients. The AP reported, "A reanalysis of research data found a high dose of popular cholesterol pill Lipitor [atorvastatin calcium] lowers risk of heart attack and stroke in .... References- http://www.pharm-education.com/2010/06/researchers-develop-vaccine-that.html http://news.bbc.co.uk/2/hi/health/8714085.stm http://www.telegraph.co.uk/health/healthnews/7786916/Breast-cancer-vaccine-to-go-on-trial-within-a-year.html http://healthday.com/Article.asp?AID=639554 http://www.timesonline.co.uk/tol/life_and_style/health/article7141155.ece http://healthday.com/Article.asp?AID=639399 http://healthday.com/Article.asp?AID=639624http://healthday.com/Article.asp?AID=639624 http://www.washingtonpost.com/wp-dyn/content/article/2010/05/31/AR2010053101874.html Disclaimer- The content of this article is intended to provide a general guide to the subject matter. Specialist advice should be sought about your specific circumstances. Http://www.drshrutibhat.com Expert at leading Pharmaceutical R&D. Translates innovative concepts to PROFITS. YouTube Channel : Http://www.youtube.com/user/ShrutiBhat10 Note : Shruti has initiated a new blog Http://www.PharmaceuticalCareerDevelopment.blogspot.com which contains articles on motivation, career counselling and coaching, job search strategies, personal branding etc. especially for pharma professionals. Do you have questions for the author?  Dr.Shruti Bhat, Leader Pharmaceutical R&D and Expert in hiTech formulation development for over 35 different therapeutic class of drugs moeities, brings to you some highlights from current pharma and clinical research news, views and data. Presented below are updates in Pharmaceutical and clinical research- Significant Differences Found In US, UK Osteoporosis Treatment Guidelines. MedWire reported that, according to a study published in the Journal of Clinical Endocrinology and Metabolism, "researchers from New Zealand have found striking differences ... New Drug Combined With Diovan May Help Lower Blood Pressure. WebMD reported that adding Novartis' AHU377, "a new kind of blood pressure drug called a vasopeptidase inhibitor," to Diovan (valsartan) "works better than either drug ... Experimental Once-A-Day Malaria Drug May Be As Effective As Twice-Daily Pill. Bloomberg News reported, "An experimental once-a-day malaria drug worked as well at treating the mosquito-borne illness as Novartis AG's twice-daily pill Coartem [artemether and lumefantrine]," according to a paper in The Lancet... Global Health Initiative To Fund Battle Against Malaria Among Children, Women In Africa. Reuters reported that through the Global Health Initiative, the government plans to focus on battling malaria, especially in African populations of women and children. Over the next six years... Vaccine That Could Help People Stop Smoking Shows Promise In Clinical Trials. CNN reported that "a vaccine designed to stimulate the immune system to generate antibodies that would latch on to nicotine in a smoker's body and prevent it from ever entering the brain" has been "showing promise in early clinical trials... Radiolabeling Conjugated Trastuzumab May Help Physicians Track Its Cancer-Fighting Progress. MedPage Today reported that "tagging a copper isotope to conjugated trastuzumab (Herceptin) might allow doctors to monitor the progress a drug is having in combating cancer," according to research presented ... Multi-Vitamins During Pregnancy May Reduce Risk Of Giving Birth To Underweight Babies. The UK's Telegraph reported that "taking multi-vitamin pills during pregnancy could significantly reduce the risk of giving birth to underweight babies." Specifically, a study of 402 pregnant women "found cases of small-for-gestational age (SGA) births were less than half as common in ... More at http://www.pharm-education.com/2010/05/vaccine-that-could-help-people-stop.html Disclaimer- The content of this article is intended to provide a general guide to the subject matter. Specialist advice should be sought about your specific circumstances. Http://www.drshrutibhat.com Expert at leading Pharmaceutical R&D. Translates innovative concepts to PROFITS. YouTube Channel : Http://www.youtube.com/user/ShrutiBhat10 Shruti has initiated a new blog Http://www.PharmaceuticalCareerDevelopment.blogspot.com which contains articles on motivation, career counselling and coaching, job search strategies, personal branding etc. especially for pharma professionals. Do you have questions for the author?  Dr.Shruti Bhat, Leader Pharmaceutical R&D and Expert in hiTech formulation development for over 35 different therapeutic class of drugs moeities, brings to you some highlights from current pharma and clinical research news, views and data. Presented below are updates in Pharmaceutical and clinical research- Pioglitazone May Slow, Stop Progression Of Insulin Resistance To Full-Blown Diabetes. According to research presented at the World Congress on Controversies to Consensus in Diabetes, Obesity, and Hypertension, "in patients with insulin resistance but near-normal glycated hemoglobin levels... Biosimilar Development Said To Be More Difficult Than Generic Endeavors. Merck & Co.'s decision to end its effort to copy Amgen Inc.'s Aranesp (darbepoetin alfa) anemia drug may highlight the difficulties drugmakers face when developing biosimilars. The FDA is ... Biotech Industry Sees Profitable Year Following Research Cuts. Bloomberg News reported "Biotechnology companies worldwide turned a profit last year for the first time since at least 1985 as those led by Celgene Corp. reduced ... Gates Invests In Drug-Software Company To Aid Drug Development. The Wall Street Journal reported Microsoft Corp. co-founder Bill Gates is investing $10 million in Schrodinger LLC, a pharmaceutical-software maker, as part of a bid to improve drug development. The investment will put Gates ... Remission In RA Possible With Biologic Drugs. MedPage Today reported that "more than half of rheumatoid arthritis patients who achieved remission during treatment with infliximab (Remicade) were able to discontinue the drug for more than a year without flaring," according to a study published online ... Methadone Use During Pregnancy Associated With Risk Of Visual Problems In Babies. MedPage Today reported that, according to a study published online in the British Journal of Ophthalmology, "infants whose ... Liraglutide Added To Metformin May Benefit Patients With Type 2 Diabetes. HealthDay reported that, according to a study published April 24 in The Lancet, "patients with type 2 diabetes who can't control their blood glucose levels with the drug metformin alone do better after adding injections of the drug liraglutide compared to oral doses of another drug called ... FDA Tightening Its Oversight Of Infusion Pumps. Food and Drug Administration officials are "moving to tighten their oversight of medical devices, including one of the most ubiquitous and problematic pieces of medical equipment," the infusion pump. Approximately ... More at ...http://www.pharm-education.com/2010/05/biosimilar-development-said-to-be-more.html Disclaimer- The content of this article is intended to provide a general guide to the subject matter. Specialist advice should be sought about your specific circumstances. Http://www.drshrutibhat.com Expert at leading Pharmaceutical R&D. Translates innovative concepts to PROFITS. YouTube Channel : Http://www.youtube.com/user/ShrutiBhat10 Do you have questions for the author?  Dr.Shruti Bhat, Leader Pharmaceutical R&D and Expert in hiTech formulation development for over 35 different therapeutic class of drugs moeities, brings to you some highlights from current pharma and clinical research news, views and data. She has initiated a new blog Http://www.PharmaceuticalCareerDevelopment.blogspot.com that would contain articles on motivation, career counselling and coaching, job search strategies, personal branding etc. Presented below are updates in Pharmaceutical and clinical research- Spanish Translations Of Prescription Information May Often Be Inaccurate Or Confusing. The Chicago Tribune reported that, "Pharmacies that print prescription labels translated in Spanish often issue inaccurate or confusing instructions that could be potentially hazardous to a patient's health, according to ... Merck To Seek FDA Approval For Five New Drugs In 2010. Bloomberg News reported that, "Merck & Co. said it will seek US regulatory approval for five new medicines this year, including new treatments for hepatitis C and diabetes." The company also ... Majority Of US' Best-Selling Drugs Are Generics. Forbes reported,, "The most popular medicine in the US," Vicodin (acetaminophen/hydrocodone), "was prescribed 128 million times last year, even as ... Abbott To License Products From Zydus Cadila To Sell In Emerging Markets. The AP reported that, Abbott Laboratories will license at least 24 products in emerging markets through a new unit created to boost sales outside of the US. Specifically, "Abbott said it will ... Basic Science May Not Be Translating Into Drug Approvals. Newsweek reported that "frustration is growing with how few seemingly promising discoveries in basic biomedical science lead to something that helps patients, especially ... Extended-Release Carvedilol May Not Increase Triglyceride Levels In Hypertensive Patients Without Dyslipidemia. MedWire reported, "Extended-release carvedilol differs to extended-release metoprolol in its effect on triglyceride levels, but has a similar impact on high-density lipoprotein (HDL) cholesterol in hypertensive patients without dyslipidemia, trial findings suggest." The study ... Newly Developed Vaccine May Reverse, Cure Malignant Melanoma. Researchers have developed a vaccine, "which will be tested on British patients over the next few months" that "can reverse and even cure malignant melanoma." The "vaccine... More at...http://www.pharm-education.com/2010/05/pharmaceutical-r-updates-newly.html Disclaimer- The content of this article is intended to provide a general guide to the subject matter. Specialist advice should be sought about your specific circumstances. Http://www.drshrutibhat.com Expert at leading Pharmaceutical R&D. Translates innovative concepts to PROFITS. YouTube Channel : Http://www.youtube.com/user/ShrutiBhat10 Do you have questions for the author?  Dr.Shruti Bhat, Leader Pharmaceutical R&D and Expert in hiTech formulation development for over 35 different therapeutic class of drugs moeities, brings to you some highlights from current pharma and clinical research news, views and data. Health Canada Issues Warning On Transdermal Patch. The Globe and Mail and The Canadian Pressreported, "A transdermal patch used to treat mild to moderate symptoms of dementia could also pose a risk of overdose, leading to nausea, hypertension, slowed heart rate or death. Health Canada ... Scientist Says Anti-Aging Drugs May Be Available In Two Years. The UK's Press Association reported that, "Medicines that can help people live healthy lives to 100 and beyond may be available in as little as two years," according to "Professor Nir Barzilai, one of the world's leading age scientists." The drugs will "involve biological pathways affecting ... Expensive Indigestion Drugs May Be Accompanied By Serious Side-Effects. The UK's Telegraph reported, "Patients who are prescribed expensive indigestion drugs" known as proton pump inhibitors "unnecessarily are risking serious side-effects." In fact, "between ... Drug-Resistant TB Strains Could Overwhelm The World Without "Significant Global Investment," Experts Warn. The UK's Press Association reported that, "A TB time bomb could explode on the world without major efforts to curb drug-resistant strains of tuberculosis, experts...warned" in a series of papers on the scourge. The "full extent of the spread of resistant TB" has not been adequately measured. But ... "Radical New Approaches" Needed To Fight TB, Experts Say. For years, the World Health Organization and partners have fought TB largely with a program where health workers watch patients take their drugs -- even though the agency acknowledged in a 2008 report that this treatment program didn't ... Disclaimer- The content of this article is intended to provide a general guide to the subject matter. Specialist advice should be sought about your specific circumstances. http://www.pharm-education.com/2010/05/radical-new-approaches-needed-to-fight.html Http://www.drshrutibhat.com Expert at leading Pharmaceutical R&D. Translates innovative concepts to PROFITS. YouTube Channel : Http://www.youtube.com/user/ShrutiBhat10 Do you have questions for the author?  Dr.Shruti Bhat, Leader Pharmaceutical R&D and Expert in hiTech formulation development for over 35 different therapeutic class of drugs moeities, brings to you some highlights from current pharma and clinical research news, views and data. FDA Approves Novel Asthma Treatment. USFDA recently approved the "first non-drug asthma treatment- Alair." According to the developer the procedure known as "bronchial thermoplasty" would "only be appropriate for about two million adults with severe asthma who don't get relief from existing drugs." The device, delivers radiofrequency energy directly to the airways, heating and reducing the thickness of lung tissue and improving users' ability to breathe ... FDA Approves Mylan, Teva Flomax Generics. Mylan Inc. and Teva Pharmaceutical Industries Ltd. "reported lately that, they are started selling their own versions of Flomax [tamsulosin HCl], a drug that treats enlarged prostate ... Cancer Risk After Kidney Transplant Similar From All Antirejection Drugs. According to a study published in the April 29 issue of the Journal of the American Society of Nephrology, "the type of drug treatment used to prevent organ rejection in kidney transplant patients doesn't affect cancer risk." Researchers arrived at this conclusion ... Obese Children May Metabolize Common Medications At Different Rates Than Leaner Children. According to a study presented at the Experimental Biology annual meeting, "children who are obese appear to metabolize common medications at different rates than their leaner counterparts." After "evaluating the metabolism of active ingredients found ... Risk For Low-Dose Aspirin-Associated Peptic Ulcer May Be Higher In Elderly Women. The risk for low-dose aspirin (LDA)-associated peptic ulcer is higher in elderly women," according to a study in the World Journal of Gastroenterology that included 453 patients who underwent esophagogastroduodenoscopy. ... More at http://www.pharm-education.com/2010/05/risk-for-low-dose-aspirin-associated.html Disclaimer- The content of this article is intended to provide a general guide to the subject matter. Specialist advice should be sought about your specific circumstances. Http://www.drshrutibhat.comExpert at leading Pharmaceutical R&D. Translates innovative concepts to PROFITS. YouTube Channel : Http://www.youtube.com/user/ShrutiBhat10 Do you have questions for the author?  Dr.Shruti Bhat, Leader Pharmaceutical R&D and Expert in hiTech formulation development for over 35 different therapeutic class of drugs moeities, brings to you some highlights from current pharma and clinical research news, views and data. FDA To Decide On Therapeutic Cancer Vaccine. Prostate cancer strikes more American men than any other cancer. In fact, "just last year there were nearly 200,000 new cases" and "more than 27,000 deaths." But ... Concurrent Use Of PPIs, Clopidogrel In Heart Disease Linked To Fewer Gastroduodenal Bleeding Hospitalizations. Concurrent use of proton pump inhibitors (PPIs) in patients with serious coronary heart disease treated with clopidogrel is associated with fewer hospitalizations for gastroduodenal bleeding," Vanderbilt researchers found after reviewing data on "20,596 patients (including 7,593 concurrent users of clopidogrel and PPIs) who received clopidogrel between 1999 and 2005... Metformin May Improve Ability Of Bicalutamide To Slow Proliferation In Hormone-Resistant Prostate Cancer Cell Lines. The commonly prescribed anti-diabetes drug metformin appears to improve the ability of bicalutamide (Casodex), an androgen ablation drug, to slow proliferation in hormone-resistant prostate cancer cell lines," according to a study presented ... NSAID Use May Not Reduce Risk Of Ovarian Cancer. Regular use of anti-inflammatory drugs did not reduce the risk of ovarian cancer," according to a study presented at the American Association for Cancer Research meeting. Researchers found that "neither weekly nor daily use of aspirin... References- http://www.pharm-education.com/2010/04/pharmaceutical-research-updates.html Disclaimer- The content of this article is intended to provide a general guide to the subject matter. Specialist advice should be sought about your specific circumstances. Http://www.drshrutibhat.com Expert at leading Pharmaceutical R&D. Translates innovative concepts to PROFITS. YouTube Channel : Http://www.youtube.com/user/ShrutiBhat10 Do you have questions for the author? | The pharmaceutical business is yet another dynamic venture, present globally and extremely important to research scientists, investors and the entire community at large.  ArchivesAugust 2010 Categories |
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